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Regulation of HHLA2 expression in kidney cancer and myeloid cells

Abstract Background The immune checkpoint HERV-H LTR-associating 2 (HHLA2) is expressed in kidney cancer and various other tumor types. Therapeutics targeting HHLA2 or its inhibitory receptor KIR3DL3 are being developed for solid tumors, including renal cell carcinoma (RCC). However, the regulation...

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Autori principali: Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Kathleen M. Mahoney
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-10-01
Serie:BMC Cancer
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Accesso online:https://doi.org/10.1186/s12885-023-11496-9
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