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Surrogate to predict overall survival in patients with BRAF V600E-mutant colorectal cancer treated with BRAF inhibitor combinations

Background: The BRAF V600E mutation, found in up to 12% of patients with metastatic colorectal cancer, is associated with aggressive disease and poor response to standard chemotherapy. However, the advent of BRAF inhibitors has led to improved clinical outcomes and survival. While surrogate endpoint...

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Principais autores: J. Ros, V. Navarro, G. Villacampa, I. Baraibar, F. Salvà, M. Rodriguez, C. Vaghi, A. Garcia, A. Alcaraz, J. Tabernero, E. Élez, R. Dienstmann
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-09-01
coleção:ESMO Gastrointestinal Oncology
Assuntos:
surrogate markers
BRAF mutation
colorectal cancer
targeted therapy
BRAF inhibitor
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2949819825000949
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