ALIX and ITCH localize to the base of primary cilia and negatively regulate ciliary Polycystin-2 levels

Abstract Primary cilia are antenna-like organelles that function as cellular hubs for signaling pathways, including Sonic hedgehog and signaling mediated by the Polycystin-1/Polycystin-2 cation channel complex. Proper regulation of signaling output depends on the dynamic control of ciliary protein c...

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Autori principali:	Christina Rahlff Berggreen, Julie Laplace, Fabiola Campestre, Anna-Louise With Petersen, Anna Maria Fixdahl, Benjamin Mary, Saba Ghazanfar, Geyi Li, Lotta Elisabeth Wagner, Csenge K. Rezi, Mohamed Chamlali, Zeinab Anvarian, Søren T. Christensen, Helen L. May-Simera, Lotte B. Pedersen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-02-01
Serie:	BMC Molecular and Cell Biology
Soggetti:	ALIX Primary cilia KIF13B Polycystin-2 ITCH Bardet-Biedl syndrome
Accesso online:	https://doi.org/10.1186/s12860-026-00571-1
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