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Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3

DNA methyltransferase 3A (DNMT3A) is shown to efficiently methylate recombinant mononucleosome linker DNA and a role for H3K36me3 in the stimulation of DNA methylation is revealed that is independent of its interaction with the PWWP domain.

Furkejuvvon:
Bibliográfalaš dieđut
Váldodahkkit: Alexander Bröhm, Tabea Schoch, Michael Dukatz, Nora Graf, Franziska Dorscht, Evelin Mantai, Sabrina Adam, Pavel Bashtrykov, Albert Jeltsch
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2022-03-01
Ráidu:Communications Biology
Liŋkkat:https://doi.org/10.1038/s42003-022-03119-z
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