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Intracranial response to positive end-expiratory pressure is influenced by lung recruitability and gas distribution during mechanical ventilation in acute brain injury patients: a proof-of-concept physiological study

Abstract Background The effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) dynamics in patients with acute brain injury (ABI) remains controversial. PEEP can benefit oxygenation by promoting alveolar recruitment, but its influence on ICP is complex. The primary aims of...

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Principais autores: Reka Bencze, Rafael Kawati, Anders Hånell, Anders Lewen, Per Enblad, Henrik Engquist, Kristin Jona Bjarnadottir, Odin Joensen, Annelie Barrueta Tenhunen, Filip Freden, Laurent Brochard, Gaetano Perchiazzi, Mariangela Pellegrini
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2025-04-01
coleção:Intensive Care Medicine Experimental
Assuntos:
Acute brain injury
Mechanical ventilation
Lung–brain interaction
Intracranial pressure
Lung mechanics
Acesso em linha:https://doi.org/10.1186/s40635-025-00750-y
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