Upregulated HCN currents and reduced intrinsic excitability in prefrontal cortical pyramidal neurons after maternal separation

The prefrontal cortex (PFC) is a core region regulating emotion, is linked to pathological mood disorders, and is a target for antidepressant drugs. Neonatal maternal separation (MS) is an early-life chronic stressor leading to anxiety and depression in adolescence. Previous studies have shown that...

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Главные авторы:	Xing Wang, Fei Luo, Baoming Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-12-01
Серии:	Neurobiology of Disease
Предметы:	Maternal separation Pyramidal cell Intrinsic excitability HCN channel Prelimbic cortex Mice
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S0969996125004036
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