Development of a HPLC-MS/MS Method to Assess the Pharmacokinetics and Tumour Distribution of the Dimethylarginine Dimethylaminohydrolase 1 Inhibitors ZST316 and L-257 in a Xenograft Model of Triple-Negative Breast Cancer in Mice

We describe the development and validation of an HPLC-MS/MS method to assess the pharmacokinetics and tumour distribution of ZST316, an arginine analogue with inhibitory activity towards dimethylarginine dimethylaminohydrolase 1 (DDAH1) and vasculogenic mimicry, and its active metabolite L-257 in a...

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Autors principals:	Tommaso Ceruti, Roberta Frapolli, Carmen Ghilardi, Alessandra Decio, Giulia Dellavedova, Sara Tommasi, Massimo Zucchetti, Arduino A. Mangoni
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-12-01
Col·lecció:	Molecules
Matèries:	ZST316 L-257 dimethylarginine dimethylaminohydrolase 1 DDAH1 inhibitors triple-negative breast cancer pharmacokinetics
Accés en línia:	https://www.mdpi.com/1420-3049/28/24/8056
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