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Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

We report the development of a 384-well formatted NanoBRET assay to characterize molecular glues of 14-3-3/client interactions in living cells. The seven isoforms of 14-3-3 are dimeric hub proteins with diverse roles including transcription factor regulation and signal transduction. 14-3-3 interacts...

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Autori principali: Holly R. Vickery, Johanna M. Virta, Markella Konstantinidou, Michelle R. Arkin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-07-01
Serie:SLAS Discovery
Soggetti:
NanoBRET
Bioluminescence energy transfer
14-3-3
PPI
Molecular glue
Stabilization
Accesso online:http://www.sciencedirect.com/science/article/pii/S2472555224000273
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