MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements

Abstract Background Entrectinib is an effective drug for treating solid tumors with NTRK gene rearrangement and non‐small cell lung cancer (NSCLC) with ROS1 gene rearrangement. However, its efficacy is limited by tolerance and acquired resistance, the mechanisms of which are not fully understood. Th...

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Hauptverfasser:	Yohei Takumi, Sachiko Arai, Chiaki Suzuki, Koji Fukuda, Akihiro Nishiyama, Shinji Takeuchi, Hiroki Sato, Kunio Matsumoto, Kenji Sugio, Seiji Yano
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2023-03-01
Schriftenreihe:	Cancer Medicine
Schlagworte:	entrectinib HGF MET NTRK ROS1
Online-Zugang:	https://doi.org/10.1002/cam4.5342
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