Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs

Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent recurrent genital lesions and concerns about transmitting infection to intimate partners affect the quality of life of infected individuals. Thera...

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Principais autores:	Sita Awasthi, Motoyasu Onishi, John M. Lubinski, Bernard T. Fowler, Alexis M. Naughton, Lauren M. Hook, Kevin P. Egan, Masaki Hagiwara, Seiki Shirai, Akiho Sakai, Takayuki Nakagawa, Kumiko Goto, Osamu Yoshida, Alisa J. Stephens, Grace Choi, Gary H. Cohen, Kazufumi Katayama, Harvey M. Friedman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-05-01
Colecção:	Viruses
Assuntos:	therapeutic vaccine herpes simplex virus type 2 glycoprotein D adjuvant genital herpes HSV-2 DNA shedding
Acesso em linha:	https://www.mdpi.com/1999-4915/15/5/1148
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