Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Abstract Background TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease progression in AD and higher CSF levels of sTREM2 are linked to slower c...

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Váldodahkkit:	Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Dan Can, Che-Feng Chang, Yun-wu Zhang, Huaxi Xu, Guojun Bu, Li Zhong, Xiao-Fen Chen
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2021-12-01
Ráidu:	Journal of Neuroinflammation
Fáttát:	Microglia Amyloid plaque sTREM2
Liŋkkat:	https://doi.org/10.1186/s12974-021-02340-7
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