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Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition

IntroductionApproximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss-of-function mutations occur in ~40% of BRAFV600E melanomas, resulting in i...

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Principais autores: Evan DuBose, Samantha M. Bevill, Dana K. Mitchell, Noah Sciaky, Brian T. Golitz, Shelley A. H. Dixon, Steven D. Rhodes, James E. Bear, Gary L. Johnson, Steven P. Angus
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-05-01
Serier:Frontiers in Oncology
Fag:
melanoma
kinase inhibitor
drug synergy
ERBB3
resistance
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1191217/full
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