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SIRT1 prevents noise-induced hearing loss by enhancing cochlear mitochondrial function

Abstract Exposure to traumatic noise triggers cochlear damage and consequently causes permanent sensorineural hearing loss. However, effective treatment strategies for noise-induced hearing loss (NIHL) are lacking. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that plays a critical role in multi...

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Furkejuvvon:
Váldodahkkit: Yuelian Luo, Haoyang Wu, Xin Min, Yi Chen, Wenting Deng, Minjun Chen, Chuxuan Yang, Hao Xiong
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-04-01
Ráidu:Cell Communication and Signaling
Fáttát:
SIRT1 conditional knockout
Noise-induced hearing loss
Mitochondrial dysfunction
Sensory hair cells
AAV
Liŋkkat:https://doi.org/10.1186/s12964-025-02152-9
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