Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl <i>N</i>-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice

TRPC6 (transient receptor potential cation channels; canonical subfamily C, member 6) is widespread localized in mammalian tissues like kidney and lung and associated with progressive proteinuria and pathophysiological pulmonary alterations, e.g., reperfusion edema or lung fibrosis. However, the und...

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Bibliografiske detaljer

Principais autores:	Xiao-Ning Chai, Friedrich-Alexander Ludwig, Anne Müglitz, Michael Schaefer, Hai-Yan Yin, Peter Brust, Ralf Regenthal, Ute Krügel
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2021-03-01
Serier:	Pharmaceuticals
Fag:	channelopathies larixol labdane LC-MS/MS mice pharmacokinetics
Online adgang:	https://www.mdpi.com/1424-8247/14/3/259
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