Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells

BackgroundMicroRNAs (miRNAs) in Schwann cells (SCs) mediate peripheral nerve function. Ablating Dicer, a key gene in miRNA biogenesis, in SCs causes peripheral neuropathy. Exosomes from healthy SCs (SC-Exo) ameliorate diabetic peripheral neuropathy in part via miRNAs. Thus, using transgenic mice wit...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lei Wang, XueRong Lu, Alexandra Szalad, Xian Shuang Liu, Yi Zhang, Xinli Wang, William Anthony Golembieski, Brianna Powell, Mikkala Mccann, Mei Lu, Michael Chopp, Zheng Gang Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-09-01
Schriftenreihe:	Frontiers in Cellular Neuroscience
Schlagworte:	dicer Schwann cells exosomes microRNAs peripheral neuropathy mice
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fncel.2024.1462228/full
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