Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

Abstract Background Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal tissue. Colitis associated col...

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Hauptverfasser:	Mai Iwaya, Hiroyoshi Ota, Tomoyuki Nakajima, Takeshi Uehara, Robert Riddell, James Conner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2021-02-01
Schriftenreihe:	BMC Cancer
Schlagworte:	Inflammatory bowel disease Ulcerative colitis Crohn’s disease Colitis associated colorectal carcinoma LGR5
Online-Zugang:	https://doi.org/10.1186/s12885-021-07835-3
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