Estrogen receptor β deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells

The incidence of ulcerative colitis (UC) is significantly higher among individuals with colonic estrogen receptor β (ERβ) deficiency, such as postmenopausal women, but the involvement of ERβ deficiency in UC pathogenesis remains obscure. Here, we showed that colonic ERβ expression level in UC patien...

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Detalhes bibliográficos

Principais autores:	Yilei Guo, Yue He, Yanrong Zhu, Wenjie Zhang, Haochang Lin, Mianjiang Zhao, Jiafeng Zhang, Yawen Bai, Zhifeng Wei, Yufeng Xia, Yue Dai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-12-01
coleção:	Redox Biology
Assuntos:	Ulcerative colitis Susceptibility Estrogen receptor β Epithelial cell senescence Mitochondrial fission Phytoestrogen
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221323172500432X
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