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Post-translational modification networks in tumor radiosensitivity: mechanistic insights and therapeutic opportunities

Abstract Background Radiotherapy is a central modality in cancer management, yet intrinsic and acquired radioresistance and dose-limiting normal tissue toxicities continue to constrain durable tumor control. Beyond genetic and transcriptional programs, post-translational modifications (PTMs) provide...

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Principais autores: Xiaoli Lv, Jiao Xue, Jun Zhou, Qi Zhao, Yandong Liu, Lili Wang, Yang Jiao, Songbing Qin
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Journal of Translational Medicine
Fag:
Post-translational modifications
Tumor radiosensitivity
DNA damage response
Radiosensitization
Therapeutic targets
Online adgang:https://doi.org/10.1186/s12967-025-07641-6
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