Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh
An enhancer named MFCS1 regulates Sonic hedgehog (Shh) expression in the posterior mesenchyme of limb buds. Several mutations in MFCS1 induce ectopic Shh expression in the anterior limb bud, and these result in preaxial polydactyly (PPD). However, the molecular basis of ectopic Shh expression remain...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2017-09-01
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| Seri Bilgileri: | G3: Genes, Genomes, Genetics |
| Konular: | |
| Online Erişim: | http://g3journal.org/lookup/doi/10.1534/g3.117.044669 |
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