A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer’s Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial

BackgroundNormal saline (NS) and Ringer’s lactate (RL) are the most common crystalloids given to hospitalized patients. Despite concern about possible harm associated with NS (eg, hyperchloremic metabolic acidosis, impaired kidney function, and death), few large multicenter r...

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Main Authors:	Julia F Shaw, Yongdong Ouyang, Dean A Fergusson, Tracy McArdle, Claudio Martin, Deborah Cook, Ian D Graham, Steven Hawken, Colin J L McCartney, Kusum Menon, Raphael Saginur, Andrew Seely, Ian Stiell, Alison Fox-Robichaud, Shane English, John Marshall, Kednapa Thavorn, Monica Taljaard, Lauralyn A McIntyre
Format:	Artigo
Language:	Inglês
Published:	JMIR Publications 2023-10-01
Series:	JMIR Research Protocols
Online Access:	https://www.researchprotocols.org/2023/1/e51783
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