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Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71

Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16. Seven chimeric EV-A71 (ChiE71) involving VP1 BC (45.5% similarity), DE, EF, GH and HI loops, VP2 EF loop and VP3 G...

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Principais autores: Xiu Hui Tan, Wei Lim Chong, Vannajan Sanghiran Lee, Syahril Abdullah, Kartini Jasni, Saiful Qushairi Suarni, David Perera, I-Ching Sam, Yoke Fun Chan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-08-01
Serier:Vaccines
Fag:
enterovirus A71
coxsackievirus A16
enterovirus
hand
foot and mouth disease
capsid loop
Online adgang:https://www.mdpi.com/2076-393X/11/8/1363
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