Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Abstract Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface. Overactivation of this system contributes to thrombosis and inflammation in numerous diseas...

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Hauptverfasser:	Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2022-10-01
Schriftenreihe:	Research and Practice in Thrombosis and Haemostasis
Schlagworte:	clotting factors contact system intrinsic coagulation kallikrein kininogen
Online-Zugang:	https://doi.org/10.1002/rth2.12815
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