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A multimodal iPSC platform for cystic fibrosis drug testing

Hundreds of mutations in the gene CFTR lead to cystic fibrosis and represent a challenge to developing therapeutics. Here, authors demonstrate the ability of airway cells derived from human iPSCs to model genotype-specific CFTR function as well as pharmacologic rescue of disease causing mutations.

Tallennettuna:
Päätekijät: Andrew Berical, Rhianna E. Lee, Junjie Lu, Mary Lou Beermann, Jake A. Le Suer, Aditya Mithal, Dylan Thomas, Nicole Ranallo, Megan Peasley, Alex Stuffer, Katherine Bukis, Rebecca Seymour, Jan Harrington, Kevin Coote, Hillary Valley, Killian Hurley, Paul McNally, Gustavo Mostoslavsky, John Mahoney, Scott H. Randell, Finn J. Hawkins
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2022-07-01
Sarja:Nature Communications
Linkit:https://doi.org/10.1038/s41467-022-31854-8
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