Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure o...

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Detalles Bibliográficos

Principais autores:	Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2016-06-01
Series:	EBioMedicine
Assuntos:	CBFβ RUNX PPI Transcription factor inhibitor Leukemia Triple negative breast cancer
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S235239641630175X
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