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Construction and evaluation of STZ-induced diabetes and diabetic kidney disease models in C57BL/6J mice

ObjectiveTo explore the optimal strategy for streptozotocin (STZ)-induced models of diabetes mellitus (DM) and Diabetic kidney disease (DKD) in C57BL/6J mice, and to analyze potential factors influencing model stability.MethodsForty-five 6-week-old male C57BL/6J mice were randomly assigned to six gr...

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Main Authors: Hao Li, Fang Qin, Shanshan Zheng, Jing Wu, Sen Lin, Xinyuan Gao, Yipeng Liu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-12-01
Series:Frontiers in Endocrinology
Subjects:
C57BL/6J mice
diabetes mellitus
diabetic nephropathies
models animal
streptozotocin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1711035/full
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