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Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during <italic toggle="yes">Mycobacterium tuberculosis</italic> Infection

ABSTRACT Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF−/−) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased susceptibility to tuberculosis in otherwise health...

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Principais autores: Alissa C. Rothchild, Britni Stowell, Girija Goyal, Cláudio Nunes-Alves, Qianting Yang, Kadamba Papavinasasundaram, Christopher M. Sassetti, Glenn Dranoff, Xinchun Chen, Jinhee Lee, Samuel M. Behar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017-11-01
coleção:mBio
Assuntos:
GM-CSF
Mycobacterium tuberculosis
T cells
cytokines
lung infection
macrophages
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.01514-17
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