Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers

Background: Polygenic scores (PGS) are becoming an increasingly popular approach to predict complex disease risk, although they also hold the potential to develop insight into the molecular profiles of patients with an elevated genetic predisposition to disease. Methods: We sought to construct an at...

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Үндсэн зохиолчид:	Si Fang, Michael V Holmes, Tom R Gaunt, George Davey Smith, Tom G Richardson
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2022-10-01
Цуврал:	eLife
Нөхцлүүд:	polygenic risk scores metabolic signatures Mendelian randomization circulating biomarkers
Онлайн хандалт:	https://elifesciences.org/articles/73951
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