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Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest. Here, we show how these enzymes distinguish between isomeric 2′- and 3′-phosphate derivatives, a difference used to improve the spe...

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Wedi'i Gadw mewn:
Prif Awduron: Raoul Manuel, Michelle de Souza Lima, Sébastien Dilly, Sylvain Daunay, Patricia Abbe, Elodie Pramil, Stéphanie Solier, Fabienne Guillaumond, Sarah-Simha Tubiana, Alexandre Escargueil, João Antonio Pêgas Henriques, Nathalie Ferrand, Irène Erdelmeier, Jean-Luc Boucher, Gildas Bertho, Israel Agranat, Stéphane Rocchi, Michèle Sabbah, Anny Slama Schwok
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2021-05-01
Cyfres:Antioxidants
Pynciau:
fluorescence
molecular modeling
cancer cell migration
NADPH oxidases
NO-synthases
in vivo imaging
Mynediad Ar-lein:https://www.mdpi.com/2076-3921/10/5/723
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