Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in human plasma by LCâMS/MS to support a bioequivalence study
A simple, precise and rapid liquid chromatographyâtandem mass spectrometry (LCâMS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oseltamivir carboxylate, a neuraminidase inhibitor, using their deuterated analogs as internal standards (ISs). The meth...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2013-06-01
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| coleção: | Journal of Pharmaceutical Analysis |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2095177912001414 |
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