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RNF12 activates Xist and is essential for X chromosome inactivation.

In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females. Initiation of random X chromosome inactivation (XCI) is thought to be regulated by X-encoded activators and autosomall...

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Главные авторы: Tahsin Stefan Barakat, Nilhan Gunhanlar, Cristina Gontan Pardo, Eskeatnaf Mulugeta Achame, Mehrnaz Ghazvini, Ruben Boers, Annegien Kenter, Eveline Rentmeester, J Anton Grootegoed, Joost Gribnau
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2011-01-01
Серии:PLoS Genetics
Online-ссылка:http://europepmc.org/articles/PMC3029249?pdf=render
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