Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor
Abstract RyR1 is an intracellular Ca2+ channel important in excitable cells such as neurons and muscle fibers. Ca2+ activates it at low concentrations and inhibits it at high concentrations. Mg2+ is the main physiological RyR1 inhibitor, an effect that is overridden upon activation. Despite the sign...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2024-05-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-024-48292-3 |
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