Artificial intelligence-based tumor-stroma ratio quantification reveals prognostic value and stromal-driven immunosuppression in colorectal cancer: an international validation study

Abstract Background Colorectal cancer (CRC) exhibits high heterogeneity, affecting variable outcomes and response to therapy. Tumor stroma drives progression and immunosuppression. Although tumor–stroma ratio (TSR) is a validated prognostic marker, TSR remains subjective and poorly reproducible. Art...

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Autors principals:	Huifen Ye, Ke Zhao, Yanfen Cui, Zhenhui Li, Huan Zhang, Min-Er Zhong, Chuanwen Fan, Haitao Huang, Nicholas J. Hawkins, Robyn L. Ward, Xiao-Feng Sun, Jinming Song, Zaiyi Liu, Jitendra Jonnagaddala, Tong Tong, Su Yao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-01-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Deep learning Whole-slide images Tumor-stroma ratio Colorectal cancer Immune
Accés en línia:	https://doi.org/10.1186/s12967-026-07681-6
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