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Alcohol-related hepatitis induces a specific fibrosis profile through YAP activation in myofibroblasts

Background & Aims: Yes-associated protein (YAP) impairs hepatocyte regeneration in alcohol-related hepatitis (AH), but its impact on fibrogenesis remains to be characterized. Our aim here was to describe fibrogenesis and investigate the impact of altered hepatocytes on fibrogenic mechanisms duri...

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Principais autores: Line Carolle Ntandja Wandji, Mohamed Bou Saleh, Cyril Sobolewski, Mehdi El Amrani, Fabrice Bray, Emmanuel Boleslawski, Jérôme Eeckhoute, Pierre-Jean Devaux, François Maggiotto, Solenne Taront, Christian Rolando, Viviane Gnemmi, Philippe Mathurin, Laurent Dubuquoy, Alexandre Louvet
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:JHEP Reports
Fag:
Alcohol-related hepatitis
Alcohol-related cirrhosis
Organoids
Fibrosis
Hippo/YAP
3D culture
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555925002629
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