Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common. Ho...

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Detalhes bibliográficos

Principais autores:	Felix Ditzinger, Daniel J. Price, Anita Nair, Johanna Becker-Baldus, Clemens Glaubitz, Jennifer B. Dressman, Christoph Saal, Martin Kuentz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-11-01
coleção:	Pharmaceutics
Assuntos:	glass forming ability hot melt extrusion mesoporous silica amorphous stability supersaturation
Acesso em linha:	https://www.mdpi.com/1999-4923/11/11/577
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