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Hierarchical Targeting Nanodrug with Holistic DNA Protection for Effective Treatment of Acute Kidney Injury

Abstract Acute kidney injury (AKI) manifests a hallmark pathological feature of extensive and severe DNA damage in renal tubules, primarily induced by the excessive of toxic reactive oxygen species (ROS) from the mitochondrial electron transport chain. The kidney's complex intricate physiological ar...

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Principais autores: Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Changkun Huang, Jianlin Chen, Jue Wang, Ziyu Wu, Wan Zeng, Chenxi Miao, Xiaojing Shi, Yayun Nan, Qiong Huang, Kelong Ai
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-02-01
Serier:Advanced Science
Fag:
AKI
antioxidative nanomedicine
mitochondria
nucleus
oxidative stress
subcellular organelle targeting
Online adgang:https://doi.org/10.1002/advs.202411254
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