Mesenchymal stem/stromal cells overexpressing leukemia inhibitory factor (LIF) promote arteriogenesis and functional recovery in a mouse model of critical hindlimb ischemia

Abstract Background Critical limb ischemia (CLI) is the most severe manifestation of peripheral arterial disease (PAD), for which there are still no effective therapeutic options. Mesenchymal stem/stromal cells (MSCs) can secrete bioactive molecules capable of promoting tissue regeneration and neova...

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Main Authors:	Girlaine Café Santos, Carine Machado Azevedo, Tiago Oliveira Ribeiro, Beatriz dos Santos Costa, Ivanilson Pimenta Santos, Mila Oliveira Nascimento, Rosane Borges Dias, Daniela Nascimento Silva, Rosalia Mendez-Otero, Vitor Fortuna, Milena Botelho Pereira Soares
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-11-01
Series:	Stem Cell Research & Therapy
Subjects:	Mesenchymal stem/stromal cells LIF Arteriogenesis Critical hindlimb ischemia
Online Access:	https://doi.org/10.1186/s13287-025-04762-z
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