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Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides

To rationalize the antiviral actions of plant alkaloids, the ability of 20 compounds to inhibit calcium-mediated fusion of lipid vesicles composed of phosphatidylglycerol and cholesterol was investigated using the calcein release assay and dynamic light scattering. Piperine, tabersonine, hordenine,...

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Principais autores: Egor V. Shekunov, Svetlana S. Efimova, Natalia M. Yudintceva, Anna A. Muryleva, Vladimir V. Zarubaev, Alexander V. Slita, Olga S. Ostroumova
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-10-01
Serier:Biomedicines
Fag:
alkaloids
membrane fusion
viral fusion inhibitor
antiviral therapy
COVID-19
Online adgang:https://www.mdpi.com/2227-9059/9/10/1434
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