Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

<h4>Unlabelled</h4>Estradiol 17ß-D-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways play complem...

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Auteurs principaux:	Ismael R Barosso, Andrés E Zucchetti, Andrea C Boaglio, M Cecilia Larocca, Diego R Taborda, Marcelo G Luquita, Marcelo G Roma, Fernando A Crocenzi, Enrique J Sánchez Pozzi
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2012-01-01
Collection:	PLoS ONE
Accès en ligne:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209816/?tool=EBI
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