Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease

IntroductionSjögren’s disease (SjD) is the second most prevalent rheumatic disease and is characterized by autoimmune pathology targeting the tear-producing lacrimal glands, leading to chronic ocular surface disease. Despite important advances, lacrimal gland pathology in SjD remains incompletely un...

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Hauptverfasser:	Shivali Gupta, Athanasios Ploumakis, Nikolaos Kalavros, Sharmila Masli
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-03-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	acinar epithelial cells antigen presenting cells autoimmunity duct epithelial cells lacrimal gland Sjögren’s disease
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1759347/full
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