Desflurane post-conditioning inhibits HMGB1 nucleocytoplasmic translocation via the SIRT1/HMGB1 axis to attenuate hepatic ischemia-reperfusion-induced acute lung injury in young rats

Acute lung injury (ALI) is a common clinical complication in pediatric patients undergoing perioperative liver transplantation, and therapeutic approaches are limited. While desflurane exhibits organ-protective potential, its specific efficacy against hepatic ischemia-reperfusion (HIR)-induced ALI i...

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Principais autores:	Yimei Cao, Yingli Cao, Hongyin Du, Hengchang Ren, Xiangming Che
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	acute lung injury desflurane hepatic ischemia-reperfusion high mobility group protein B1 silent information regulator 2 related enzyme 1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1847195/full
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