Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose

ObjectiveThis study aims to investigate the influence of intrafraction DNA damage repair on biologically effective dose (BED) in Ir-192 high-dose-rate (HDR) brachytherapy (BT) for cervical cancer. Specifically, we examine BED variations resulting from source decay at various treatment time points ac...

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Autores principales:	Suyan Bi, Jiaomei Zhou, Meiling Xu, Zhitao Dai
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-05-01
Colección:	Frontiers in Oncology
Materias:	high-dose-rate brachytherapy (HDR BT) cervical cancer source decay impact tumor cell lines intrafraction damage repair biological effective dose (BED)
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1407606/full
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