Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

Abstract Defective functionality of thymic epithelial cells (TECs), due to genetic mutations or injuring causes, results in altered T‐cell development, leading to immunodeficiency or autoimmunity. These defects cannot be corrected by hematopoietic stem cell transplantation (HSCT), and thymus transpl...

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書誌詳細

主要な著者:	Ileana Bortolomai, Monica Sandri, Elena Draghici, Elena Fontana, Elisabetta Campodoni, Genni Enza Marcovecchio, Francesca Ferrua, Laura Perani, Antonello Spinelli, Tamara Canu, Marco Catucci, Tiziano Di Tomaso, Lucia Sergi Sergi, Antonio Esposito, Angelo Lombardo, Luigi Naldini, Anna Tampieri, Georg A. Hollander, Anna Villa, Marita Bosticardo
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 2019-10-01
シリーズ:	Stem Cells Translational Medicine
主題:	3D collagen scaffolds Lentiviral vector Thymic epithelial cells Thymic regeneration
オンライン･アクセス:	https://doi.org/10.1002/sctm.18-0218
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