Third generation EGFR TKIs: current data and future directions

Abstract Acquired T790 M mutation is the commonest cause of resistance for advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutant patients who had progressed after first line EGFR TKI (tyrosine kinase inhibitor). Several third generation EGFR TKIs which are EGFR m...

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Auteurs principaux:	Chee-Seng Tan, Nesaretnam Barr Kumarakulasinghe, Yi-Qing Huang, Yvonne Li En Ang, Joan Rou-En Choo, Boon-Cher Goh, Ross A. Soo
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2018-02-01
Collection:	Molecular Cancer
Sujets:	Third generation EGFR TKI T790 M Osimertinib Resistance mechanism FLAURA Sequencing
Accès en ligne:	http://link.springer.com/article/10.1186/s12943-018-0778-0
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