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Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

Abstract Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target...

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Principais autores: Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh, Ajaz A. Bhat
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-07-01
Serier:Journal of Translational Medicine
Fag:
CAR-T cell therapy
Immunotherapy
Tumor antigens
Antigen escape
Cytokine release syndrome
Hematological malignancy
Online adgang:https://doi.org/10.1186/s12967-023-04292-3
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