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TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis

Abstract Background Transmembrane protein 43 (TMEM43), a member of the transmembrane protein subfamily, plays a critical role in the initiation and development of cancers. However, little is known concerning the biological function and molecular mechanisms of TMEM43 in pancreatic cancer. Methods In...

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Main Authors: Junqiang Li, Yang Song, Chao Zhang, Ronglin Wang, Lei Hua, Yongdong Guo, Dongxue Gan, Liaoliao Zhu, Shanshan Li, Peixiang Ma, Cheng Yang, Hong Li, Jing Yang, Jingjie Shi, Xiaonan Liu, Haichuan Su
Format: Artigo
Language:Inglês
Published: BMC 2022-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
Pancreatic cancer
Progression
TMEM43
PRPF3
RAP2B
Online Access:https://doi.org/10.1186/s11658-022-00321-z
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