Human pluripotent stem cell-derived intestinal organoids for pharmacokinetic studies

The human small intestine is essential for orally administered drugs' absorption, metabolism, and excretion. Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cells (IECs) offer a useful model for evaluating drug candidate compounds. We previously reported a protocol to gener...

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Principais autores:	Takumi Saito, Junichiro Amako, Teruhiko Watanabe, Nobuaki Shiraki, Shoen Kume
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-06-01
coleção:	European Journal of Cell Biology
Assuntos:	in vitro differentiation Induced pluripotent stem cells Intestine Organoid Enterocyte Intestinal stem cells
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0171933525000147
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