ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia

Abstract Background Owing to their transcription factor binding sites, endogenous retroviruses (ERVs) can act as cis-regulatory-elements (CREs). By invading genomes in waves, ERVs offer a substrate for lineage-specific adaptations but also, when dysregulated, for lineage-specific disorders. Their ro...

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Hlavní autoři:	Rabia Anwar, Amit Pande, Manvendra Singh, Zhi Huang, Eve Hallett, Yiran Xie, Alexandra Gellhaus, Florian Herse, Olivia Nonn, Martin Gauster, Tamás Raskó, Matthias Selbach, Stefan Verlohren, Anne Cathrine Staff, Ralf Dechend, Ulrich Pecks, Sandra M. Blois, Laurence D. Hurst, Zsuzsanna Izsvák
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-11-01
Edice:	Genome Biology
On-line přístup:	https://doi.org/10.1186/s13059-025-03821-1
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