Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target?

Co-crystal structures of a base-excision DNA-repair enzyme (human 8-oxoguanine DNA glycosylase; hOgg1) in complex with a photocaged 8-oxoguanine DNA lesion were determined before and after uncaging via illumination at 2.81 and 2.48 Å resolution, respectively. The structures were carefully reassessed...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Tomoki Imura, Yuhei Hosokawa, Kai-Chun Yang, Yuki Ban, Hsuan-Yu Shih, Junpei Yamamoto, Manuel Maestre-Reyna
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	International Union of Crystallography 2025-09-01
Sarja:	IUCrJ
Aiheet:	dna repair photocaged substrate analogs hogg1 intermediate trapping
Linkit:	https://journals.iucr.org/paper?S2052252525006062
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