Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice

Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from th...

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Detalhes bibliográficos

Principais autores:	Lisa E. Gralinski, Vineet D. Menachery, Andrew P. Morgan, Allison L. Totura, Anne Beall, Jacob Kocher, Jessica Plante, D. Corinne Harrison-Shostak, Alexandra Schäfer, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Ralph S. Baric
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2017-06-01
coleção:	G3: Genes, Genomes, Genetics
Assuntos:	SARS-CoV Collaborative Cross F2 Ticam2 host susceptibility genes Multi-parent Advanced Generation Inter-Cross (MAGIC) multiparental populations MPP
Acesso em linha:	http://g3journal.org/lookup/doi/10.1534/g3.117.041434
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