Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF

Connective tissue growth factor (CTGF) is notably upregulated in scar tissue, making it a promising target for therapeutic intervention. Here, we have designed and screened an antisense oligonucleotide (ASO) that binds specifically to the exon five sequence of CTGF, with particular emphasis on the u...

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Principais autores:	Jinhe Li, Xi Wu, Ying Yang, Ruiqi Mao, Zherui Li, Xiujun Zhang, Wenguo Wei, Wendi Wang, Hailong Li, Honggang Zhou, Cheng Yang
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2025-08-01
叢編:	Frontiers in Pharmacology
主題:	CTGF antisense oligonucleotide scar LNA fibrosis
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1623640/full
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